Efficacy of platelet rich plasma on graft uptake in myringoplasty

Document Type : Original Article

Authors

Department of otorhinolaryngology, Faculty of Medicine, Ain Shams University

Abstract

Background: The purpose of this research is to compare the effectiveness of platelet-rich plasma (PRP) with conventional temporalis fascia myringoplasty in the treatment of medium-sized central perforations in the central tympanic membrane (TM). This study was designed as a randomized control trial.
Patients and methods: We used a retro-auricular approach underlay graft employing temporalis fascia to perform myringoplasty on fifty-two patients with chronic otitis media (COM) mucosal-type, medium-sized central TM perforation, and conductive hearing loss. We randomly assigned these patients to either with PRP or without PRP procedures.
Results; Graft uptake, or an intact TM, was the main result six weeks after surgery. The analysis includes 52 myringoplasties (control group-26 patients, intervention group-26 patients) performed on 52 patients (34 males and 18 females, ages 25–47).  Graft uptake rates were 92.3% in the intervention and 84.6% in control group) six weeks after surgery. Graft uptake did not differ statistically significantly between the two groups (P value = 0.418).  Both groups experienced comparable postoperative complications. 
Conclusions: Graft-uptake in the intervention group and problems were comparable to those of control group. When it comes to treating TM perforation, intervention group has no advantages over the control group.
 

Keywords

Files

Share

How to cite

Statistics